KANAZOL
Syrup

Anthelmintic

  • Chemical Composition

    Mebendazole 100 mg / 5ml

  • Packing

    30ml/Glass Bottle

  • Medical Id

    SY-12

  • License Number

    542/2005

  • License date

    26/9/2005

Mechanism Of Action Mebendazole is a broad-spectrum anthelmintic. It appears to affect the cytoplasmic microtubules of the tegumental or intestinal cells of parasitic worms resulting in a transport blocking of secretory vesicles. This may lead to impaired coating of the membranes followed by a decreased digestion and absorption of nutrients, e.g. glucose, thereby depleting the energy level until it is inadequate for survival.
INDICATIONS KANAZOLE is indicated for the treatment of single and mixed helminth infestations caused by: – nematodes such as: – Trichuris trichiura (whipworm) – Ancylostoma duodenale (hookworm) – Necator americanus (hookworm) – Ascaris lumbricoides (large roundworm) – Ternidens deminutus – Enterobius vermicularis (pinworm) – Strongyloides stercoralis (threadworm) – cestodes such as: – Taenia spp (tapeworm) – infestations by Moniliformis moniliformis
CONTRAINDICATIONS In persons who have shown sensitivity to mebendazole or other petrimidazole derivatives. KANAZOLE should not be given during pregnancy.
Side EFFECTS Rare cases involving very heavy threadworm infestations a KANAZOLE treatment can produce transient symptoms including diarrhea, vomiting, and abdominal pain. Other possible side effects are rare because mebendazole is poorly absorbed by the intestine but may include a loss of appetite, vomiting, drowsiness, headache or dizziness. Hypersensitivity reactions such as exanthema, rash, urticaria and angio-oedema have been observed
WARNINGS KANAZOLE should not be taken by children under two years of age and it should not be taken during pregnancy and lactation. Symptoms of an allergic reaction may include swelling, extreme dizziness or difficulty breathing.
DRUG INTERACTIONS : Concomitant treatment with cimetidine may inhibit the metabolism of the mebendazole in the liver, resulting in increased plasma concentrations of the drug especially during prolonged treatment. In the latter case, determination of plasma concentrations is recommended in order to allow dose adjustments. Caution should also be taken if the anticonvulsant Carbamazepine is used concomitantly.
Pregnancy And lactations KANAZOLE should not be given during pregnancy
Dosage And Administration Whipworm; Hookworm; Large Roundworm; Pinworm; Ternidens deminutus; Infestations by Moniliformis moniliformis: One tablet or one teaspoonful (5 ml) twice daily (morning and evening) for three consecutive days. The standard dosage applies to adults, children and infants. Tapeworm (Taenia spp): One tablet or one teaspoonful (5 ml) twice daily (morning and evening) for six consecutive days. The standard dosage applies to adults, children and infants. Threadworm (Strongyloides stercoralis): Adults: Two tablets or two teaspoonful (10 ml) twice daily (morning and evening) for three consecutive days. Children: One teaspoonful (5 ml) twice daily (morning and evening) for three consecutive days. KANAZOLE oral suspension has a banana flavour that is easily accepted by children and adults alike and may be used as a substitute for tablets
OVERDOSE : In the event of accidental overdosage, abdominal cramps, nausea, vomiting and diarrhoea may occur. If poisoning or excessive overdosage is suspected it is recommended, on general principles, that vomiting be induced or gastric lavage be performed, and such symptomatic supportive therapy be administered as appears indicated. Activated charcoal may be given
Storage Conditions - Store below 30° Cin a dry place - Keep out of reach of children