Non – opioid analgesics and antipyretics

  • Chemical Composition

    Chlorphneramine maleate1mg- Paracetamol 160mg-Pseudoephedrine HCL15mg

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Mechanism Of Action Chlorpheniramine, is an antihistamine that blocks the histamine's access to the secretory cells and thus provide relief of the allergy symptoms. It also has a mild drying effect on mucous membranes, which relieves the runny nose and nasal congestion. Pseudoephedrine is a decongestant that constricts the blood vessels of the mucosal lining of the nose and sinus and significantly decreases secretions. Paracetamol is a clinically proven analgesic/antipyretic. It reduces the production of prostaglandins (hormone-like chemicals) in the brain. Prostaglandins are believed to be linked to fever, pain, and inflammation. Paracetamol does not reduce the number of prostaglandins produced throughout the body and is not effective in relieving inflammation.
INDICATIONS KANAWATI KANADOL Cold oral solution is indicated for the relief of symptoms of nasal stuffiness, runny nose, sneezing, minor aches and pains, headaches and fever due to the common cold, hay fever or other nasal allergies
CONTRAINDICATIONS -Paracetamol should not be used in patients with severe liver disease. -Do not use this product if you are being treated with monoamine oxidase inhibitors, or within two weeks of stopping treatment with these medications.
Side EFFECTS Paracetamol may cause allergic reactions in the form of a rash or blood disorders (including neutropenia, pancytopenia and leucopenia). These should disappear on stopping the treatment. The rash usually appears as red areas or allergic wheals, and may be accompanied by fever and involvement of the mucous membranes. Pseudoephedrine may cause giddiness, headache, nausea, vomiting, sweating, thirst, rapid or irregular heart beat, pain in front of the heart, palpitations, raised blood pressure, difficulty in urination, muscular weakness, tremors, anxiety, restlessness and inability to sleep. Chlorpheniramine may cause sedation, lassitude, dizziness, incoordination; central nervous system stimulation (insomnia, nervousness, euphoria, irritability, tremors, nightmares, hallucinations and convulsions) especially in children; antimuscarinic effects (e.g. dry mouth, thickened respiratory-tract secretions and tightness of the chest, blurred vision, urinary difficulty and retention, disturbances affecting the stomach and intestines resulting in constipation, and increased gastric reflux); vomiting, diarrhoea, epigastric pain, nausea and anorexia; headache; ringing in the ears; parathesias (tingling sensation); and hypotension (low blood pressure).
WARNINGS Taking more than the recommended dose may cause severe liver damage. Patients suffering from liver or kidney disease should take paracetamol only if instructed to do so by the doctor. This medicine may lead to drowsiness and impaired concentration. Chlorpheniramine should be given with care to patients with raised pressure in the eye (glaucoma), difficulty in passing urine, enlargement of the prostate gland, pyloroduodenal obstruction, patients with epilepsy or severe cardiovascular disorders. Be careful when taking medicines containing, tricyclic antidepressants or atropine together. Do not use continuously for longer than 10 days without consulting your doctor. Do not take concurrent medication containing paracetamol.
DRUG INTERACTIONS The effects of pseudoephedrine are lessened by medicines containing guanethidine, reserpine, methyldopa and may be diminished or enhanced by tricyclic antidepressants. It may increase the possibility of irregular heart beat in patients taking digitalis. Concomitant use of antihistamines with tranquilizers or sedatives could increase the effect of drowsiness. Concomitant use of antihistamines and anticholinergics may increase the effect of dry mouth. Antihistamines used in combination with monoamine oxidase inhibitors (MAOIs) may increase the severity of the side effects associated with these drugs. Decongestants combined with MAOIs may cause serious cardiovascular effects
Dosage And Administration Adults only and children above 12 years old : One teaspoon ( 5 ml ). Doses may be repeated every 6 hours as needed (only one teaspoon) Do not exceed 4 doses in 24 hours. FOR CHILDREN: DOCTOR’S CONSULTATION IS NECESSARY. Prescription only
Storage Conditions - store below 25°C in a dry place away of light . - Protect from light . - keep out of reach of children