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Anti infective & antibacterial drugs

  • Chemical Composition

    Clindamycin phosphate 11.85 mg Equivalent Clindamycin Base 10 mg/ 1ml

  • Packing

    25ml/Glass Bottle

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Mechanism Of Action : Clindamycin may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of the infection and the susceptibility of the infecting organism. Clindamycin palmitate, hydrochloride or phosphate are inactive until hydrolyzed to free clidamycin this occurs very rapidly in vivo. Clindamycin appears to inhibit protein synthesis in suceptible organisms by binding to 50S ribosomal subunits; the primary effect is inhibition of peptide bond formation.
INDICATIONS Acnemycin Topical Solution is indicated in the treatment of mild to moderate acne. Clindamycin helps reduce the bacteria that contribute to acne. It is also anti-flammatory agent
CONTRAINDICATIONS Acnemycin Topical Solution is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin .
Side EFFECTS More common side effects may include burning, itching, peeling skin, reddened skin, and skin dryness. Less common or rare side effects may include abdominal pain, diarrhea, colitis, oily skin, skin inflammation and irritation, stomach and intestinal disturbances
WARNINGS : Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. Acnemycin topical solution contains an alcohol base which will cause burning and irritation of the eye. In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), bathe with copious amounts of cool tap water. The solution has an unpleasant taste and caution should be exercised when applying medication around the mouth. Acnemycin should be used with caution in patients with hay fever, asthma, or eczema. As well as patiens with a history of regional entavitis or ulcerative colitis , or a history of antibiotic-associated colitis . If the acne does not improve within about 6 weeks, or if it becomes worse, check with the health care professional. However, treatment of acne may take up to 8 to 12 weeks before full improvement is seen. Safety and effectiveness in children under the age of 12 has not been established
DRUG INTERACTIONS Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, the two drugs should not be administered concurrently.
Pregnancy And lactations Safety use during pregnancy and breast-feeding has not been established, therefore, it should be used during pregnancy only if clearly needed, and the breast-feeding should be discontinued while using this medication.
Dosage And Administration Wash the affected area and pat dry with a clean towel, and then apply a thin film of Acnemycin topical solution to affected area (entire area) twice daily, by using the applicator.
OVERDOSE Topically applied clindamycin phosphate can be absorbed in sufficient amounts to produce systemic effects. If you suspect an overdose, seek medical attention immediately.
Storage Conditions Store below 30° C , Keep out of reach of children