KANADINE
Tablets

Non- Opioid Analgesics And Antipyretics

  • Chemical Composition

    Paracetamol 500 mg - Codeine phosphate 8 mg

  • Packing

    20Tablets

  • Medical Id

    T38

  • License Number

    5/2005

  • License date

    6/1/2005

Mechanism Of Action KANADINE contains two active ingredients, paracetamol and codeine phosphate. Paracetamol is a clinically proven analgesic/antipyretic. Paracetamol produces analgesia by elevation of the pain threshold and antipyresis through action on the hypothalamic heat regulating centre. Codeine and other opioids mimic the effects of naturally occurring pain reducing chemicals (endorphins) that are found in the brain and spinal cord. They act on the opioid receptors in the brain and block the transmission of pain signals. This combination is used to reduce fever and to relieve mild to moderate pain caused by a variety of conditions (e.g. headache, toothache, neuralgia, migraine, period pains).
INDICATIONS KANADINE is indicated for the relief of fever (pyrexia), and mild to moderate pain.
CONTRAINDICATIONS -Hypersensitivity to any of the ingredients. -Paracetamol should not be used in patients with severe liver and kidney diseases.
Side EFFECTS The most common side effects associated sometimes and in some patients, with this product include: - Constipation - Drowsiness - Nausea - Blood disorders - Damage to the liver - Skin rashes - Inflammation of the pancreas (pancreatitis).
WARNINGS : Alcohol increases the risk of liver damage that can occur if an overdose of paracetamol is taken. The hazards of paracetamol overdose are greater in persistant heavy drinkers and in people with alcoholic liver disease. Don't take other preparations also containing paracetamol. Use with caution in patients with decreased kidney function and decreased liver function. Codeine is able to produce physiological drug dependence similar to morphine dependence. Tolerance, psychological dependence and physiological dependence can occur with recurrent administration. Codeine also impairs mental alertness and physical coordination.
DRUG INTERACTIONS An excessive intake of alcohol may increase the damage to the liver when taken with paracetamol. Cholestyramine may reduce the absorption of paracetamol from the gut. Paracetamol may increase the effects of warfarin and other anti-coagulant medicines. Regular monitoring should be performed. Use with tricyclic antidepressants, antihistamines, sedatives, other narcotic analgesics, muscle relaxants, or alcohol can enhance sedation. The use of anti cholinergics with codeine can produce paralytic ileus
Pregnancy And lactations -Do not take this product during pregnancy or whilst breast-feeding.
Dosage And Administration Adults and children over 12 years: 1-2 tablets 3-4 times daily. Do not exceed the recommended dose. Do not take more than 2 at any one time. Do not take more than 8 in 24 hours. Not recommended for children under 12 years of age.
OVERDOSE Adults and children over 12 years: 1-2 tablets 3-4 times daily. Do not exceed the recommended dose. Do not take more than 2 at any one time. Do not take more than 8 in 24 hours. Not recommended for children under 12 years of age.
Storage Conditions Store below 25° C Keep out of reach of children Prescription Only Medicine