Antithrombotic drugs

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    Aspirin 75 mg

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Mechanism Of Action : Aspirin is a salicylate that has demonstrated anti-inflammatory, analgesic, antipyretic, and antirheumatic activity, It also has antithrombotic effects. Aspirin's mode of action may be due to the inhibition of cyclo-oxygenase, which is responsible for the biosynthesis of the prostaglandin hormones. Therefore, aspirin inhibits the synthesis and release of prostaglandins.
INDICATIONS KANASPIRIN-75 mg is used for the secondary prevention of thrombotic cerebrovascular or cardiovascular disease, following by-pass surgery and in patients suffering from unstable angina.
CONTRAINDICATIONS Aspirin should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or non-steroidal anti-inflammatory agents. Aspirin should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia). In addition, it should not be given to patients who are taking anticoagulant drugs.
Side EFFECTS : Most common side effects include heartburn, GI pain, nausea, and irritations or ulceration in the stomach mucous membrane. Therefore, it is preferable to take Aspirin after meals. Aspirin may cause Gl bleeding, which may develop to anaemia, these symptoms disappear when the product is discontinued. Hypersensitivity symptoms may occur in patients with hypersensitivity to aspirin and other NSAID's. Aspirin increases the bleeding time and decreases the platelet aggregation
WARNINGS KANASPIRIN-75 mg should be administered with caution to patients with renal failure, hepatic function disorders, asthma, or bleeding disorders KANASPIRIN-75 mg is not indicated for use in children and young people less than 16 years of ag
DRUG INTERACTIONS : Aspirin increases the activity of oral anticoagulants and heparin. Moreover, it increases the anti-hyperglycemic sulphamides activity, therefore the dose of such drugs should be reduced or they should be given with 2 hours interval. Aspirin may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone. Sodium excretion produced by spironolactone may be decreased in the presence of salicylates. Alcohol has a synergistic effect with aspirin in causing gastrointestinal bleeding. Concomitant administration of corticosteroids with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels. Urinary alkalinizers decrease aspirin effectiveness by increasing the rate of salicylate renal excretion. Phenobarbital decreases aspirin effectiveness by enzyme induction. Serum phenytoin levels may be increased by aspirin
Pregnancy And lactations Aspirin should not be given to pregnant women and nursing mothers
Dosage And Administration Adults: The usual dosage for long term use is 1-2 tablets (75-150mg), to be dissolved in a glass of water once daily. In some circumstances a higher dose may be appropriate, especially in the short-term treatment, and up to 4 tablets (300mg) a day may be used on the advice of a doctor.
OVERDOSE : Symptoms of overdose depend upon plasma salicylate concentration. They include tinnitus, vertigo, hyperventilation, metabolic acidosis, coma, fever, hypothrombinaemia, cardiovascular collapse, and renal failure. Treatment - Aspirin may remain in the stomach for many hours after ingestion and should be removed by gastric lavage. Plasma salicylate, pH and electrolytes should be measured. Fluid losses replaced and forced alkaline diuresis (eg with sodium bicarbonate) should be considered when the plasma salicylate concentration is greater than 500mg/l. In very severe cases of poisoning haemodialysis may be needed
Storage Conditions Store below 30° C in a dry place