Antithrombotic drugs

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    Aspirin 325 mg

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Mechanism Of Action Aspirin is a salicylate that has demonstrated antiinflammatory, analgesic, antipyretic, and antirheumatic activity. Aspirin's mode of action may be due to the inhibition of cyclo-oxygenase, which is responsible for the biosynthesis of the prostaglandin hormones. Therefore, aspirin inhibits the synthesis and release of prostaglandins. Aspirin appears to produce analgesia and antipyresis by its effect at a hypothalamic site in the brain.
INDICATIONS KANASPIRIN-81 mg, KANASPIRIN-100 mg are used as anti-platelet for the prevention of myocardial infarction. They are also indicated for reducing the risk of recurrent transient ischemic attacks (TIAs) or stroke in men who have transient ischemia of the brain due to fibrin emboli. KANASPIRIN-325 mg is used as an analgesic, antipyretic, and anti-inflammatory. It is given for the relief of headache, toothache, menstrual pain, and pain associated with cold, influenza, and rheumatoid arthritis.
CONTRAINDICATIONS Aspirin should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or nonsteroidal antiinflammatory agents. Aspirin should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia). In addition, it should not be given to patients who are taking anticoagulant drugs.
Side EFFECTS Most common side effects include heartburn, GI pain, nausea, and irritations or ulceration in the stomach mucous membrane. Therefore, it is preferable to take Aspirin after meals. Aspirin may cause Gl bleeding, which may develop to anaemia, these symptoms disappear when the product is discontinued. Hypersensitivity symptoms may occur in patients with hypersensitivity to aspirin and other NSAID's. Aspirin increases the bleeding time and decreases the platelet aggregation.
WARNINGS KANASPIRIN should be administered with caution to patients with renal failure, hepatic function disorders, asthma, or bleeding disorders
DRUG INTERACTIONS Aspirin increases the activity of oral anticoagulants and heparin. Moreover, it increases the anti-hyperglycemic sulphamides activity, therefore the dose of such drugs should be reduced or they should be given with 2 hours interval. Aspirin may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone. Sodium excretion produced by spironolactone may be decreased in the presence of salicylates. Alcohol has a synergistic effect with aspirin in causing gastrointestinal bleeding. Concomitant administration of corticosteroids with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels. Urinary alkalinizers decrease aspirin effectiveness by increasing the rate of salicylate renal excretion. Phenobarbital decreases aspirin effectiveness by enzyme induction. Serum phenytoin levels may be increased by aspirin.
Pregnancy And lactations Aspirin should not be given to pregnant women and nursing mothers.
Dosage And Administration Adults and Children 12 years and over: One or two tablets of KANASPIRIN-325 mg daily, with water. May be repeated every four hours as necessary up to 12 tablets a day or as directed by a doctor. Do not give to children under 12 unless directed by a doctor. Adults :One tablet of KANASPIRIN-81 mg or KANASPIRIN-100 mg daily, with water. As anti-thrombotic.
OVERDOSE The ingestion of 6 g of Aspirin may cause mild toxicity, but the symptoms may be delayed up to 24 hours. Drinking excessive quantities of water or fluids may treat the moderate toxicity of Aspirin. But the acute toxicity should be treated by immediate stomach lavage.
Storage Conditions Store below 30ْ in a dry place.