Non-steroidal Anti-inflammatory drugs

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    Acemetacin 60 mg

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Excipients Lactose ,Magnesium stearate
Mechanism Of Action REUMA-OFF (Acemetacine) is a glycolic acid ester of indomethacine and its pharmacological activity is due to both acemetacine and its major metabolite indomethacme. REUMA-OFF (Acemetacine) has analgesic, anti-inflammatory, and antipyretic properties due to the inhibition of cycloxygenase.
INDICATIONS REUMA-OFF (Acemetacin ) is used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis, and also in the short-term management of conditions like bursitis, tendonitis, and acute gouty arthritis. It is also given for the relief of pain, oedema, and inflammation following orthopaedic procedures, in addition to the mild to moderate pain in conditions such as dysmenorrhoea. REUMA-OFF (Acemetacin) has been also given as an adjunct to opioides in the management of postoperative pain.
CONTRAINDICATIONS : Hypersensitivity to the components. REUMA-OFF (Acemetacin) should not be used in patients in whom acute asthmatic attacks, or urticaris have been precipitated by aspirin or other NSAID's; active gastrointestinal bleeding
Side EFFECTS : Most common side effects are GI pain, dyspepsia, nausea, diarrhoea constipation, flatulence, anorexia, rash, pruritis, dizziness, headache, and nervousness
WARNINGS : As with other (NSAIDs) acemetacine should not be given to patients with peptic ulcer or a history of gastro-intestinal lesions. REUMA-OFF (Acemetacin) may mask the symptoms of infection, therefore, it should be used with caution in patients with existing infection. It should not be given to pregnant or nursing women. Administration to children or to elderly is not recommended. REUMA-OFF should be used with caution in patients with epilepsy, parkinsonism, and other psychotic disorders. Patients receiving long term treatment should be periodically screened for renal and hepatic function and blood count. Eye changes may occur in chronic rheumatoid disease and patients should receive periodic ophthalmological examinations and therapy discontinued if changes occur. The ability to drive a car or operate machinery may be affected during treatment with acemetacin.
Dosage And Administration Concurrent administration of aspirin decreases acemetacin blood concentrations by about 20%. Administration of diflunisal with acemetacin decreases the renal function and increases plasma concentrations of acemetacine. Moreover, concurrent use of acemetacin and diflunisal resulted in fatal gastrointestinal haemorrhage. Concurrent use with anticoagulants and other NSAID's is not recommended. Dosage & Administration: One capsule (60 mg) 2-3 times daily with fluids after food. Or according to physician instructions.
Storage Conditions -Store between 15- 30 C. - Store away from light and moisture. - Keep out of reach of children