Anti-anemia Drugs

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    Folic acid 5 mg

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Excipients Lactose , Corn starch , Avicel 101 , Croscarmellose sodium , Gelatin , P.V.P , H.P.M.C, C.M.C , Sodium starch glycolate , Mg stearate , Talc .
Mechanism Of Action Antianemia drug Clinical Pharmacology : Folic Acid acts on megaloblastic bone marrow to produce a normoblastic marrow. In man, an exogenous source of folate is required for nucleoprotein synthesis and the maintenance of normal erythropoiesis. Folic Acid is the precursor of tetrahydroFolic Acid, which is involved as a cofactor for transformylation reactions in the biosynthesis of purines and thymidylates of nucleic acids. Impairment of thymidylate synthesis in patients with Folic Acid deficiency is thought to account for the defective deoxyribonucleic acid (DNA) synthesis that leads to megaloblast formation and megaloblastic and macrocytic anemias.
INDICATIONS Folic Acid is effective in the treatment of megaloblastic anemias due to a deficiency of Folic Acid (as may be seen in tropical or nontropical sprue) and in anemias of nutritional origin, pregnancy, infancy, or childhood.
CONTRAINDICATIONS Folic Acid is contraindicated in patients who have shown previous intolerance to the drug.
Side EFFECTS Allergic sensitization has been reported following both oral and parenteral administration of Folic Acid. Folic Acid is relatively nontoxic in man. Rare instances of allergic responses to Folic Acid preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm . Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic Acid daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic Acid therapy
WARNINGS Administration of Folic Acid alone is improper therapy for pernicious anemia and other megaloblastic anemias in which vitamin B12 is deficient. Precautions: General: Folic Acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurologic manifestations remain progressive. There is a potential danger in administering Folic Acid to patients with undiagnosed anemia, since Folic Acid may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress. This may result in severe nervous system damage before the correct diagnosis is made. Adequate doses of vitamin B12 may prevent, halt, or improve the neurologic changes caused by pernicious anemia.
DRUG INTERACTIONS There is evidence that the anticonvulsant action of phenytoin is antagonized by Folic Acid. A patient whose epilepsy is completely controlled by phenytoin may require increased doses to prevent convulsions if Folic Acid is given. Folate deficiency may result from increased loss of folate, as in renal dialysis and/or interference with metabolism (e.g., Folic Acid antagonists such as methotrexate); the administration of anticonvulsants, such as diphenylhydantoin, primidone, and barbiturates; alcohol consumption and, especially, alcoholic cirrhosis; and the administration of pyrimethamine and nitrofurantoin. False low serum and red cell folate levels may occur if the patient has been taking antibiotics, such as tetracycline, which suppress the growth of Lactobacillus casei.
Pregnancy And lactations Teratogenic Effects : Pregnancy Category A Folic Acid is usually indicated in the treatment of megaloblastic anemias of pregnancy. Folic Acid requirements are markedly increased during pregnancy, and deficiency will result in fetal damage .Studies in pregnant women have not shown that Folic Acid increases the risk of fetal abnormalities if administered during pregnancy. If the drug is used during pregnancy, the possibility of fetal harm appears remote. Because studies cannot rule out the possibility of harm, however, Folic Acid should be used during pregnancy only if clearly needed. Nursing Mothers: Folic Acid is excreted in the milk of lactating mothers. During lactation, Folic Acid requirements are markedly increased; however, amounts present in human milk are adequate to fulfill infant requirements, although supplementation may be needed in low- birth- weight infants, in those who are breast-fed by mothers with Folic Acid deficiency (50 mcg daily), or in those with infections or prolonged diarrhea.
Dosage And Administration Oral administration is preferred. Although most patients with malabsorption cannot absorb food folates, they are able to absorb Folic Acid given orally. Parenteral administration is not advocated but may be necessary in some individuals (e.g., patients receiving parenteral or enteral alimentation). Doses greater than 0.1 mg should not be used unless anemia due to vitamin B12 deficiency has been ruled out or is being adequately treated with a cobalamin. Daily doses greater than 1 mg do not enhance the hematologic effect, and most of the excess is excreted unchanged in the urine. The usual therapeutic dosage in adults and children (regardless of age) is up to 1 mg daily. Resistant cases may require larger doses. When clinical symptoms have subsided and the blood picture has become normal, a daily maintenance level should be used, i.e., 0.1 mg for infants and up to 0.3 mg for children under 4 years of age, 0.4 mg for adults and children 4 or more years of age, and 0.8 mg for pregnant and lactating women, but never less than 0.1 mg/day. Patients should be kept under close supervision and adjustment of the maintenance level made if relapse appears imminent. In the presence of alcoholism, hemolytic anemia, anticonvulsant therapy, or chronic infection, the maintenance level may need to be increased. For the treatment of folate-deficient megaloblastic anaemia it is recommended in the UK that folic acid is given orally in doses of 5 mg daily for 4 months; up to15 mg daily may be necessary in malabsorption states. Continued oral dosage with folic acid 5 mg every 1 to7 days may be necessary in chronic haemolytic states such as thalassaemia major or sickle-cell anaemia, depending on the diet and rate of haemolysis; similar doses may be necessary in some patients receiving renal dialysis in order to prevent deficiency. In the prophylaxis of megaloblastic anaemia of pregnancy,the usual dose is 200 to 500 micrograms daily in the UK. For women of child-bearing potential at high risk of having a pregnancy affected by neural tube defect, the dose of folic acid is 4 or 5 mg daily starting before pregnancy (in the USA the recommendation is 4 weeks before) and continued through the first trimester. For other women of child-bearing potential the dose is 400 micrograms daily.
OVERDOSE Except during pregnancy and lactation, Folic Acid should not be given in therapeutic doses greater than 0.4 mg daily until pernicious anemia has been ruled out. Patients with pernicious anemia receiving more than 0.4 mg of Folic Acid daily who are inadequately treated with vitamin B12 may show reversion of the hematologic parameters to normal, but neurologic manifestations due to vitamin B12 deficiency will progress. Doses of Folic Acid exceeding the Recommended Dietary Allowance (RDA) should not be included in multivitamin preparations; if therapeutic amounts are necessary, Folic Acid should be given separately
Storage Conditions Store below 30° c , in a dry place Keep out of reach of children