Antithrombotic Drugs

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    Aspirin 81 mg

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Mechanism Of Action Aspirin is an analgesic, antipyretic, non-steroidal anti-inflammatory, and anticoagulant agent. The daily use of KANASPIRIN-81 mg may reduce the risk of cardiovascular and cerebrovascular events in subjects with a suspected myocardial infarction.
INDICATIONS KANASPIRIN-81 mg used as anti-platelet for the prevention of myocardial infarction. They are also indicated for reducing the risk of recurrent transient ischemic attacks (TIAs) or stroke in men who have transient ischemia of the brain due to fibrin emboli.
CONTRAINDICATIONS Aspirin should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or nonsteroidal antiinflammatory agents. Aspirin should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia). In addition, it should not be given to patients who are taking anticoagulant drugs.
Side EFFECTS Most common side effects include heartburn, GI pain, nausea, and irritations or ulceration in the stomach mucous membrane. Therefore, it is preferable to take Aspirin after meals. Aspirin may cause Gl bleeding, which may develop to anaemia, these symptoms disappear when the product is discontinued. Hypersensitivity symptoms may occur in patients with hypersensitivity to aspirin and other NSAID's. Aspirin increases the bleeding time and decreases the platelet aggregation.
WARNINGS KANASPIRIN should be administered with caution to patients with renal failure, hepatic function disorders, asthma, or bleeding disorders.
DRUG INTERACTIONS Aspirin increases the activity of oral anticoagulants and heparin. Moreover, it increases the anti-hyperglycemic sulphamides activity, therefore the dose of such drugs should be reduced or they should be given with 2 hours interval. Aspirin may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone. Sodium excretion produced by spironolactone may be decreased in the presence of salicylates. Alcohol has a synergistic effect with aspirin in causing gastrointestinal bleeding. Concomitant administration of corticosteroids with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels. Urinary alkalinizers decrease aspirin effectiveness by increasing the rate of salicylate renal excretion. Phenobarbital decreases aspirin effectiveness by enzyme induction. Serum phenytoin levels may be increased by aspirin.
Pregnancy And lactations Aspirin should not be given to pregnant women and nursing mothers.
Dosage And Administration Adults :One tablet of KANASPIRIN-81 mg daily, with water. As anti-thrombotic.
OVERDOSE The ingestion of 6 g of Aspirin may cause mild toxicity, but the symptoms may be delayed up to 24 hours. Drinking excessive quantities of water or fluids may treat the moderate toxicity of Aspirin. But the acute toxicity should be treated by immediate stomach lavage.
Storage Conditions Store below 30ْ in a dry place.