Anti viral agent

  • Chemical Composition

    Aciclovir 200 mg

  • Packing


  • Medical Id


  • License Number


  • License date


Mechanism Of Action : .Kana-zovak contains the active ingredient Acyclovir, which is an antiviral medicine. Acyclovir works by stopping the herpes simplex virus from reproducing and infecting more cells. Acyclovir is converted to a more active form inside cells of the body that are infected with herpes simplex. The activated Acyclovir then works by blocking the action of a viral enzyme called DNA polymerase. The herpes virus needs the DNA polymerase enzyme to copy its genetic material from RNA to DNA. This process is necessary for the virus to multiply and continue to survive. By blocking the action of DNA polymerase, Acyclovir prevents the herpes virus from multiplying. This controls the infection and helps the immune system to deal with it.
INDICATIONS Herpes Zoster Infections: Kana-zovak is indicated for the acute treatment of herpes zoster (shingles). Genital Herpes: Kana-zovak is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Chickenpox: Kana-zovak is indicated for the treatment of chickenpox (varicella).
CONTRAINDICATIONS Kana-zovak is contraindicated in patients with known hypersensitivity to Acyclovir, valacyclovir, or any component of the formulation.
Side EFFECTS Rare side effects in patients treated short-term with acyclovir are nausea, vomiting, and headache. Long-term treatment has the additional potential for rash and diarrhea. CNS disturbances (esp. elderly), vertigo, myalgia, malaise, viral resistance, and renal failure may also occur rarely.
WARNINGS Renal failure has been observed with Acyclovir therapy. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) has occurred in immunocompromised patients receiving Acyclovir therapy. Dosage adjustment is recommended when administering Acyclovir to patients with renal impairment. Caution should also be exercised when administering Acyclovir to patients receiving potentially nephrotoxic agents since this may increase the risk of renal dysfunction and/or the risk of reversible central nervous system symptoms. Herpes Zoster :There are no date on treatment initiated more than 72 horus after onset of the zoster rash .Pataients should be advised to initiate treatment as soon as Possible after a diagnosis of herpes zoster. Chickenpox : Chickenpox in otherwise healthy children is usually a self-limited disease of mild to moderate severity. Adolescents and adult tend to have more severe disease. Treatment was 24 houes of theb typical Chickenpox rash in the controlled studies, and there is no information regarding the effects of Treatment begun later in the disease course. Genital herpes is a sexually transmitted disease and patients should avoid intercourse when they have visible lesions. Resistance to acyclovir can develop, especially with overuse. Therefore, acyclovir should be used only for severe cases and only as long as needed. Long-term suppression for recurrent genital herpes should include periodic re-evaluations and trials without the drug or intermittent short-term treatments.
DRUG INTERACTIONS Coadministration of probenecid with acyclovir may increase the mean acyclovir half-life and the area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced
Pregnancy And lactations Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Acyclovir should be administered to a nursing mother with caution and only when indicated.
Dosage And Administration Acute Treatment of Herpes Zoster: Genital Herpes: Treatment of Initial Genital Herpes: 200 mg (1 capsule of Kana-Zovak -200 mg) every 4 hours, 5 times daily for 10 days. . Alternative regimens have included doses ranging from 200 mg (1 capsule of V-Rax-200 mg) 3 times daily to 200 mg (1 capsule of V-Rax-200 mg) 5 times daily. Intermittent Therapy: 200 mg (1 capsule of Kana-Zovak -200 mg) every 4 hours, 5 times daily for 5 days. Therapy should be initiated at the earliest sign or symptom (prodrome) of recurrence. Treatment of Chickenpox: Children (2 years of age and older ): 20 mg /kg per dose orally 4 times daily(80 mg/kg/day) for 5 days. Adults and Children over 40 kg When therapy is indicated, it should be initiated at the earliest sign or symptom of chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours after onset of signs and symptoms. Hemodialysis: For patients who require hemodialysis, the mean plasma half-life of Acyclovir during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule should be adjusted so that an additional dose is administered after each dialysis.
OVERDOSE : Adverse events that have been reported in association with overdosage include agitation, coma, seizures, and lethargy. Precipitation of acyclovir in renal tubules may occur when the solubility (2.5 mg/mL) is exceeded in the intratubular fluid. This has resulted in elevated BUN and serum creatinine and subsequent renal failure. In the event of acute renal failure and anuria, the patient may benefit from hemodialysis until renal function is restored.
Storage Conditions Store below 30°C. Keep out of reach of children. Prescription only medicine.