Respiratory drugs - antifungal Congestion

  • Chemical Composition

    Triprolidine HCL 2,5 mg - Pseudoephedrine HCL 60 mg

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Mechanism Of Action : Kana-Flufed contains two active ingredients, triprolidine HCl and Pseudoephedrine HCl. Triprolidine is a potent, competitive histamine H1-receptor antagonist. Pseudoephedrine has direct and indirect sympathomimetic activity and is an effective upper respiratory decongestant.
INDICATIONS Kana-Flufed is used for the symptomatic relief of upper respiratory tract disorders which are benefited by a combination of a nasal decongestant and H1-receptor antagonist, for example allergic rhinitis, vasomoter rhinitis and the common cold.
CONTRAINDICATIONS • Hypersensitivity to any component of the product. • Patients receiving MAO inhibitors or who have taken it within the preceding 2 weeks. • Patients with severe hypertension or severe coronary artery disease. • Use in patients who are currently receiving other sympathomimetic drugs. • Antihistamines should not be used to treat lower respiratory tract symptoms, including asthma.
Side EFFECTS : This product may act as a cerebral stimulant in children and occasionally adults giving rise to insomnia, nervousness, hyperpyrexia, tremors and epileptiform convulsions. Skin rashes, with or without irritation, tachycardia, dryness of mouth, nose and throat, and headache have occasionally been reported.
WARNINGS : KANA-FLUFED Tablets may cause drowsiness and impairment of alertness. Patients should be cautioned about engaging in activities requiring mental alertness, until they have established their own response to the drug. Caution should be exercised when administering to patients with severe hepatic impairment or moderate to severe renal impairment particularly if accompanied by cardiovascular disease. Although pseudoephedrine has virtually no pressor effects in patients with normal blood pressure, KANA-FLUFED Tablets should be used with caution in patients taking antihypertensive agents and tricyclic antidepressants. As with other sympathomimetic agents, KANA-FLUFED Tablets should be used with caution in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intra-ocular pressure or prostatic enlargement. Care should be taken when used in epileptic patients.
DRUG INTERACTIONS Concomitant use of KANA-FLUFED Tablets with alcohol or other central nervous system depressants may, in some individuals, produce additional impairment in mental alertness. The effects of anti-cholinergics e.g., some psychotropic drugs and atropine, may be potentiated by this product, giving rise to tachycardia, mouth dryness, gastrointestinal disturbances, e.g., colic, urinary retention and headache. Concomitant use of KANA-FLUFED Tablets with: tricyclic antidepressants, other sympathomimetic agents (such as decongestants, appetite suppressants and amphetamine-like psychostimulants) or with monoamine oxidase inhibitors (including furazolidone) may occasionally cause a rise in blood pressure. The effect of antihypertensive agents which interfere with sympathetic activity may be partially reversed by the pseudoephedrine in KANA-FLUFED Tablets, eg., bretylium, bethanidine, guanethidine, debrisoquine, methyldopa, alpha- and beta-adrenergic blocking agents.
Pregnancy And lactations Pregnancy: Kana-Flufed should be given to a pregnant woman only if clearly needed. Lactation: A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Dosage And Administration Adults and children 12 years and over: One tablet to be taken every 4-6 hours, up to four times a day.
Storage Conditions Keep below 25 C Keep out of reach of children Protect from moisture and light