Non- Opioid analgesics and antipyretics

  • Chemical Composition

    Paracetamol 250 mg

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Mechanism Of Action Paracetamol is a clinically proven analgesic/antipyretic. Paracetamol produces analgesia by elevation of the pain threshold and antipyresis through action on the hypothalamic heat regulating centre
INDICATIONS KANADOL for Children (tablets 80 mg, suppositories, syrup) are indicated for the temporary relief of simple pain such as headache, sore throat, toothache, immunizations, fever and discomfort associated with colds and flu.
CONTRAINDICATIONS Hypersensitivity to the product or any other components
Side EFFECTS Side effects with Paracetamol are rare, as it is a well tolerated medicine. But skin rashes and blood disorders have occasionally been reported. Paracetamol may cause liver necrosis due to short-time overdosage or long-term administration of the product
WARNINGS If a rare sensitivity reaction occurs, treatment with KANADOL should be stopped. KANADOL should be given with caution to patients with impaired kidney and liver function.
DRUG INTERACTIONS Interactions between paracetamol and Phenobarbital, phenytoin, or tricyclic antidepressants may occur. Caution should be exercised when paracetamol is used with drugs affecting the liver.
Dosage And Administration Children 4-5 years old: one suppository (250 mg) 3-4 times daily.
OVERDOSE Overdosages with Paracetamol is relatively common. It can result in severe liver damage and sometimes renal tubular necrosis. The metabolite (N-acetyl-p-benzoquinoneimine), which is responsible for the Paracetamol overdosage toxicity, is usually detoxified by conjugation with glutathione and excreted as mercaptopurine and cysteine conjugates. Substances like methionine and acetylcysteine, which can replenish the depleted glutathione stores, are used as antidotes in Paracetamol overdosage.
Storage Conditions - Store below 30° C In a dry place away from moisture and light . - Keep out of reach of children